The materials in this collection constitute a semi-random sample of the pre-war archive that was transferred to the Central State Archives of the Lithuanian Soviet Socialist Republic following the liquidation of the Vilnius Jewish Museum in 1949. The collection includes records of YIVO work and activities, financial records, correspondence, and publications; documents about pogroms in Ukraine, and Red Army and Soviet activity in Vilna and Bialystok; and a significant amount of records of socialist, communist, and Zionist political parties, as well as associated newspapers and one-time publications.

Hadassah Functions and Operations Records represent the bulk of aid and services provided to Hadassah's membership, from the 1920s to 2011. Materials found in the record group include correspondence, clippings, press releases, manuals and kits for chapters and members to implement programming and chapter structure, fundraising campaigns, scripts, study guides, programming for local and national meetings, biographical files, and training documentation. Departments documented in the record group include Public Affairs, Education, Women's Health, American Affairs, Zionist and International Affairs, Speakers Bureau, Fundraising, Program, Organization, Outreach and Tourism Departments. Materials related to the general administration of Hadassah are also in the record group; these materials include research and development of projects, archives department correspondence and other materials, Hadassah House administration, and strategic planning. The record group also documents Hadassah's efforts to expand membership outside of the United States, by the development of Hadassah International.

This collection contains the personal and professional papers of William Edlin, editor of The Day and a prominent Socialist. It includes correspondence with individuals and with organizations, newspaper clippings, manuscripts of works by Edlin and by others as well as translations done by Edlin, and some of Edlin’s personal documents. These materials relate to Edlin’s involvement with The Day, with the Socialist Party, the Workmen’s Circle, various labor and Zionist organizations, literary clubs and activities, and with music, art and drama.

This collection consists of assorted types of financial records, some correspondence and a few photographs related to efforts to develop the infrastructure of Israel during the 1800s, the First and Second Aliyah periods, the time of the British Mandate, and the early years after the founding of the State of Israel.

The Vilna Collection represents fragmentary materials that were part of the original YIVO Archives in Vilna before WWII. The collection includes a wide array of materials dealing with a great variety of aspects of Jewish life in the Pre-revolutionary Russian Empire and post-revolutionary Poland, Ukraine, Lithuania, and Soviet Russia. The Collection consists of personal correspondence, official correspondence with organizations and governmental institutions, financial and statistical reports, minutes of meetings of Jewish communal and political organizations, bibliographic materials, including card catalogues and bibliographies. Also included here are vital documents, such as birth certificates and birth registers, affidavits, certificates, diplomas, and travel documents. Additionally, there are petitions, resolutions, appeals, printed materials, manuscripts, lists, and questionnaires. There is a wealth of materials dealing with Jewish book trade and publishing, youth and sports organizations, education, Jewish communal life, and political activities.