The materials in this collection constitute a semi-random sample of the pre-war archive that was transferred to the Central State Archives of the Lithuanian Soviet Socialist Republic following the liquidation of the Vilnius Jewish Museum in 1949. The collection includes records of YIVO work and activities, financial records, correspondence, and publications; documents about pogroms in Ukraine, and Red Army and Soviet activity in Vilna and Bialystok; and a significant amount of records of socialist, communist, and Zionist political parties, as well as associated newspapers and one-time publications.

The Lithuanian Jewish Communities Collection is comprised of documents relating to Jewish cultural, religious, social, political, and economic life in approximately 150 towns in Lithuania. The bulk of the collection pertains to the period between 1919 and 1926, when elements of a system of Jewish national autonomy existed within the Lithuanian state, including a Ministry of Jewish Affairs and governmentally empowered Jewish community councils. Smaller parts of the collection relate to the periods before (1860-1918) and after (1927-1940) the autonomy.

The collection relates to the life of Jewish refugees, mostly of German and Austrian origin, in Shanghai primarily between the years 1939-1948. It covers many aspects of their experience, including political and cultural events, relief and charity activities, and self-help. The collection originated from the YIVO exhibition that was organized and displayed in 1947 in Shanghai and later in New York. The collection consists of manuscripts, minutes of meetings, correspondence, newspaper clippings, and printed materials.

The Vilna Collection represents fragmentary materials that were part of the original YIVO Archives in Vilna before WWII. The collection includes a wide array of materials dealing with a great variety of aspects of Jewish life in the Pre-revolutionary Russian Empire and post-revolutionary Poland, Ukraine, Lithuania, and Soviet Russia. The Collection consists of personal correspondence, official correspondence with organizations and governmental institutions, financial and statistical reports, minutes of meetings of Jewish communal and political organizations, bibliographic materials, including card catalogues and bibliographies. Also included here are vital documents, such as birth certificates and birth registers, affidavits, certificates, diplomas, and travel documents. Additionally, there are petitions, resolutions, appeals, printed materials, manuscripts, lists, and questionnaires. There is a wealth of materials dealing with Jewish book trade and publishing, youth and sports organizations, education, Jewish communal life, and political activities.