This record group contains materials related to the local units of Hadassah—groups, chapters, regions, and co-ops—as well as Junior Hadassah, a youth organization that functioned as a group within the Hadassah Chapter structure. The record group documents over one hundred years of Hadassah’s growth, and illuminates a century of American Jewish communal life, particularly that of Jewish women, across the United States. The record group reflects the formation, administration and activities of the individual groups, chapters, co-ops and regions, and contains information on local events and programs organized around fundraising, Zionism, Jewish heritage, religion and holidays celebration, the study of Hebrew and Yiddish, women's issues, fashion, health, technology and many other topics.

This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

The German-Jewish Children's Aid, later known as the European-Jewish Children's Aid, was involved in bringing Jewish children to the United States from Europe before, during, and after World War II. The records in this collection are comprised of correspondence, reports and case files, which may contain biographical information as well as questionnaries and correspondence concerning the case.

Collection contains bound records from the administrative activities of the Hebrew Infant Asylum, including annual reports, board meeting minutes, reports of the admitting physicians, and the admission and discharge records of children.

The Lavanburg-Corner House (LCH) Fund was a philanthropic fund started in 1927 under the Lavanburg Foundation. Its mission was to support/fund agencies that dealt with troubled children and youth. The LCH Fund became fully philanthropic in 1972. The collection contains bills, by-laws, correspondence, financial statements, histories, letters, meeting minutes, memorandums, newspaper clippings, proposals, publications, and reports of the Lavanburg-Corner House Fund.

Young Judaea is the oldest Zionist youth organization in the United States, established as a national organization in 1909 by the Federation of American Zionists. It was supported by Hadassah, including direct financial sponsorship from 1967-2011. The major aims of Young Judaea throughout its history have been to advance the cause of Zionism, to further the mental, moral, and physical development of Jewish youth, and to promote Jewish culture and ideals in accordance with Jewish traditions. Young Judaea has remained non-partisan and non-denominational, embracing and recruiting Jewish youth from all backgrounds.

The Youth Aliyah Records in the Hadassah Archives document Hadassah's work with multiple international organizations to rescue Jewish children from continental Europe to Palestine from 1933-1945. The collection also documents Hadassah's involvement with Youth Aliyah since 1946 in providing residential, educational, vocational, rehabilitative and therapeutic care for displaced and at-risk youth from around the world.