This record group contains materials related to the local units of Hadassah—groups, chapters, regions, and co-ops—as well as Junior Hadassah, a youth organization that functioned as a group within the Hadassah Chapter structure. The record group documents over one hundred years of Hadassah’s growth, and illuminates a century of American Jewish communal life, particularly that of Jewish women, across the United States. The record group reflects the formation, administration and activities of the individual groups, chapters, co-ops and regions, and contains information on local events and programs organized around fundraising, Zionism, Jewish heritage, religion and holidays celebration, the study of Hebrew and Yiddish, women's issues, fashion, health, technology and many other topics.

The Baron de Hirsch Fund Records document the organization's involvement in the planning of agricultural communities across the United States and to some extent in South America; the founding and administrative dealings of agricultural and trade schools; the establishment of the Jewish Agricultural Society; and the business records of the Fund itself. In addition, the collection documents the protection offered to immigrants through port work, relief, temporary aid, promotion of suburban industrial enterprises and removal from urban centers through the Industrial Removal Office, land settlement, agricultural training, and trade and general education. In this respect, the collection is of major interest for Jewish genealogists as it documents a number of individual immigrants. In addition, the collection contains documentation on the administration and organization of the fund, documentation on Jewish farming colonies such as the Jewish Agricultural Society, Woodbine Colony and Agricultural School, and documentation on the Baron de Hirsch Trade School. In addition, the collection contains blueprints and photographs of facilities.

The material in this record group was culled from Hadassah's Central Files in Israel in the early 1980s to document Hadassah's role in Zionist history. Originally formed from a Zionist women's study group, the first Hadassah chapter in New York had a strong relationship with the Zionist Organization of America (ZOA; then known as the Federation of American Zionists). The material in this record group documents Hadassah's relationship to the ZOA and to other Zionist organizations in the United States, Europe, and Palestine/Israel, particularly in the years leading up to Israeli statehood in 1948. Other subjects addressed in this record group include the founding of Hadassah; World War II, particularly relating to Jewish emigration and refugees; the founding of the United Nations and the debate over recognition of a Jewish state; the partition of Palestine; and Arab-Jewish relations. Included are articles, clippings, convention resolutions, correspondence, diary extracts, memorandums, minutes, press releases, printed ephemera, publications, reports, and speeches.