This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

The Hadassah Medical Organization Records in the Hadassah Archives document Hadassah's work in providing health care resources in Palestine/Israel since 1918. The activities documented revolve around the development of the Hadassah Hospital; health centers; dental centers; occupational and rehabilitative services; medical, nursing, dental, and pharmacy schools; as well as numerous educative and preventive projects, especially those aimed at infant care. The documents also reflect the history of the Yishuv (Jewish settlement in Palestine) and the establishment of the State of Israel. The record group contains articles, clippings, correspondence, financial records, fundraising material, minutes, personal accounts, press releases, publicity material, reports, and statistical reports.

The Baron de Hirsch Fund Records document the organization's involvement in the planning of agricultural communities across the United States and to some extent in South America; the founding and administrative dealings of agricultural and trade schools; the establishment of the Jewish Agricultural Society; and the business records of the Fund itself. In addition, the collection documents the protection offered to immigrants through port work, relief, temporary aid, promotion of suburban industrial enterprises and removal from urban centers through the Industrial Removal Office, land settlement, agricultural training, and trade and general education. In this respect, the collection is of major interest for Jewish genealogists as it documents a number of individual immigrants. In addition, the collection contains documentation on the administration and organization of the fund, documentation on Jewish farming colonies such as the Jewish Agricultural Society, Woodbine Colony and Agricultural School, and documentation on the Baron de Hirsch Trade School. In addition, the collection contains blueprints and photographs of facilities.

The Youth Aliyah Records in the Hadassah Archives document Hadassah's work with multiple international organizations to rescue Jewish children from continental Europe to Palestine from 1933-1945. The collection also documents Hadassah's involvement with Youth Aliyah since 1946 in providing residential, educational, vocational, rehabilitative and therapeutic care for displaced and at-risk youth from around the world.