The materials in this collection constitute a semi-random sample of the pre-war archive that was transferred to the Central State Archives of the Lithuanian Soviet Socialist Republic following the liquidation of the Vilnius Jewish Museum in 1949. The collection includes records of YIVO work and activities, financial records, correspondence, and publications; documents about pogroms in Ukraine, and Red Army and Soviet activity in Vilna and Bialystok; and a significant amount of records of socialist, communist, and Zionist political parties, as well as associated newspapers and one-time publications.

Mizrakh Yidisher Historisher Arkhiv Collection consists of diverse materials that pertain to pogroms in the period between 1918 and 1921 that took place mostly in Ukraine but also in Belarus, Poland, and Russia. There is a wide variety of topics that are covered in the collection including Ukrainian-Jewish relations during a short lived Ukrainian Republic, Ukrainian-Jewish political, communal, and governmental organizations, Ukrainian government and the role of politicians and military Commanders in pogroms, most notably Symon Petlyura and Ataman Grigoriev, pogroms and its aftermath, military occupation of Ukraine by the German, Polish, Bolshevik and General Denikin’s armies and its relationship to pogroms, Jewish self-defense and relief work. Also included here are materials pertaining to the trial of Sholom Schwarzbard who was tried in France for assassination of Symon Petlyura. The collection consists of of large amount of lists and eyewitness testimonies, correspondence, complaints and petitions, reports and resolutions, statements and proclamations, memoranda and circular letters, conference materials, statues and by-laws, clippings and bulletins, military orders, and photographs.

The collection documents the National Jewish Welfare Board's (JWB) evolution from an organization founded in 1917 to provide support for soldiers in times of war to an agency involved in all aspects of Jewish life both in the United States and abroad. In 1990 JWB recreated itself as the Jewish Community Centers Association of North America.

The Marc Ratner Papers consist of materials pertaining to Marc Ratner's political activities as one of the leaders of the SERP (Sotsialisticheskaya Yevreyskaya Rabochaya Partiia, Jewish Socialist Workers' Party, Rus: Социалистическая еврейская рабочая партия) which was a left leaning Zionist revolutionary party. The collection consists of correspondence, circular letters, clippings, minutes of meetings, essays, manuscripts, political resolutions and statements. The bulk of the collection consists of correspondence between party members, minutes of meetings and manuscripts.

Maxim Vinawer Papers consist of materials pertaining to Maxim Vinawer’s activities as a political and a communal leader. The collection covers the period between 1915 and 1926. These materials illuminate Vinawer’s participation in Russian politics as one of the leaders of the liberal Constitutional Democratic Party (Kadets), his appointment as a Minister of Foreign Affairs for the Crimean Regional Government in 1919, and his activities as a prominent figure among Zionist and émigré groups in Paris. The collection consists of correspondence, circular letters, memoranda, bulletins, clippings, minutes of meetings, essays, manuscripts, drafts and notes

The May Cohn Russia and Soviet Union Collection (Vilna Archives) includes materials dealing with a wide range of topics mostly pertaining to Jewish life in the Russian Empire and the Soviet Union and to a smaller extent to everyday life of ordinary Russian citizens. The collection consists of official government documents such as reports, decrees and regulations, circular letters, lists, vital records, Census records, residency and emigration permits. Also included here are manuscripts, correspondence, printed materials, petitions, announcements, posters, questionnaires, and minutes of meetings. Materials collected here shed light on the way Jewish religious and civil life was administered in the Russian Empire and the Soviet Union.