The materials in this collection constitute a semi-random sample of the pre-war archive that was transferred to the Central State Archives of the Lithuanian Soviet Socialist Republic following the liquidation of the Vilnius Jewish Museum in 1949. The collection includes records of YIVO work and activities, financial records, correspondence, and publications; documents about pogroms in Ukraine, and Red Army and Soviet activity in Vilna and Bialystok; and a significant amount of records of socialist, communist, and Zionist political parties, as well as associated newspapers and one-time publications.

The Elias Tcherikower Collection documents the professional and personal life of Elias Tcherikower, a scholar, communal activist, and one of the founders of the YIVO Institute for Jewish Research, and to a smaller extent personal life of his wife, Riva Tcherikower, née Teplitski. Collected here are Tcherikower’s writings, professional and personal correspondence, photographs, manuscripts by other scholars, research materials, printed materials, financial documents, conference and exhibit materials, minutes of meetings, bibliographic materials and personal materials of Riva Tcherikower, née Teplitski, and Chaim Tcherikower.

This collection contains manuscripts of novels, short stories, poems, essays, lectures, speeches, translations, and other writings, correspondence, photographs, and personal documents and materials of Yiddish writer Chaim Grade and his wife Inna Hecker Grade. The collection helps to illustrate Grade’s literary development and impact on Yiddish literature over time, from his earliest poetic works written in Vilna and the Soviet Union, to his prolific and accomplished prose work composed mainly in the United States. The collection illuminates Inna Grade's intellectual and academic prowess, as well as the integral role that she played in the editorial and logistical aspects of Grade's literary output.

The collection relates to the life of Jewish refugees, mostly of German and Austrian origin, in Shanghai primarily between the years 1939-1948. It covers many aspects of their experience, including political and cultural events, relief and charity activities, and self-help. The collection originated from the YIVO exhibition that was organized and displayed in 1947 in Shanghai and later in New York. The collection consists of manuscripts, minutes of meetings, correspondence, newspaper clippings, and printed materials.