The collection contains background materials pertaining to the formation of the Conference, the election of delegates, financial records, memoranda, reports, and incomplete minutes of the Conference and its committees. It also includes extensive correspondence of the Administrative Secretary Jesse B. Calmenson, for March-December, 1943. The major portion of the collection consists of transcripts of the first through fourth sessions (1943-1947) of the Plenum and committees of the Conference. The published material in the collection includes the Bulletin of the activities and Digest of the press.

The Annual and Mid-Winter National Conventions Records document the proceedings and outcomes of the conventions and conferences attended by Hadassah’s National Board as well as by convention delegates from the various regions of Hadassah. The conventions in particular are where local and regional leaders meet with each other and the National Board and learn about Hadassah’s various projects and committees. This record group also includes annual reports from 1926-2001.

This record group is made up of mostly audio and moving images materials, including ¼-inch open audio reels, 16mm film, filmstrips, cassette tapes, VHS tapes, CDs, DVDs, LPs, 3.5 inch floppy disks, and other media, dating from the 1920s up to 2010. The films and audio recordings document Hadassah's efforts to publicize themselves to their members and those outside of Hadassah, by raising awareness of their history, fundraising efforts, and projects in United States and Israel, especially the Hadassah Medical Organization and Youth Aliyah projects and programs. Hadassah also used recordings to document important proceedings, including departmental and board meetings, Midwinter Conferences, and National Conventions.

This record group documents the work of the Hadassah national board through board and executive committee meeting minutes, board member subject files, correspondence and reports, as well as minutes and materials generated by Hadassah ad-hoc and non-Executive committees, from 1912-2012. This record group also includes files from milestone anniversaries of Hadassah and legal documents pertaining to its projects.

Hadassah Functions and Operations Records represent the bulk of aid and services provided to Hadassah's membership, from the 1920s to 2011. Materials found in the record group include correspondence, clippings, press releases, manuals and kits for chapters and members to implement programming and chapter structure, fundraising campaigns, scripts, study guides, programming for local and national meetings, biographical files, and training documentation. Departments documented in the record group include Public Affairs, Education, Women's Health, American Affairs, Zionist and International Affairs, Speakers Bureau, Fundraising, Program, Organization, Outreach and Tourism Departments. Materials related to the general administration of Hadassah are also in the record group; these materials include research and development of projects, archives department correspondence and other materials, Hadassah House administration, and strategic planning. The record group also documents Hadassah's efforts to expand membership outside of the United States, by the development of Hadassah International.