This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

The Hadassah subject file record group is a collection of files of organizations, events, and genre subjects originally arranged alphabetically by Hadassah’s central filing department. These files served and serve as a ready reference source that represents both the direct and indirect involvement of Hadassah in both national and international affairs. This collection includes correspondence, clippings, newsletters, photographs, and other ephemeral documents.

This record group contains meeting minutes, correspondence and reports of the Hadassah Council in Israel (originally the Hadassah Emergency Services and the Hadassah Council in Palestine), the Hadassah Youth Services (originally the Palestine Council of Hadassah) and the Hadassah Youth Services (HYS) successor organizations, Hadassah Vocational Education Services (HVES) and Hadassah Israel Education Services (HIES). The records represent the activities of Hadassah's representatives in Palestine/Israel, from 1927 to the 1990s. The Hadassah Youth Services focused on providing services to underserved youth in Palestine/Israel, most notably with their school luncheon and Guggenheimer playground programs. After HYS changed its working name to HVES in 1952, it began to focus on vocational education projects in Israel. Legally, however, the name of the organization in Israel remained Hadassah Youth Services. The Hadassah Council in Israel acted as an advisor and liaison between Hadassah's American offices and Hadassah's Israel projects, including the Hadassah Medical Organization, Youth Aliyah, and Hadassah Youth Services.

The Youth Aliyah Records in the Hadassah Archives document Hadassah's work with multiple international organizations to rescue Jewish children from continental Europe to Palestine from 1933-1945. The collection also documents Hadassah's involvement with Youth Aliyah since 1946 in providing residential, educational, vocational, rehabilitative and therapeutic care for displaced and at-risk youth from around the world.