This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

This record group contains meeting minutes, correspondence and reports of the Hadassah Council in Israel (originally the Hadassah Emergency Services and the Hadassah Council in Palestine), the Hadassah Youth Services (originally the Palestine Council of Hadassah) and the Hadassah Youth Services (HYS) successor organizations, Hadassah Vocational Education Services (HVES) and Hadassah Israel Education Services (HIES). The records represent the activities of Hadassah's representatives in Palestine/Israel, from 1927 to the 1990s. The Hadassah Youth Services focused on providing services to underserved youth in Palestine/Israel, most notably with their school luncheon and Guggenheimer playground programs. After HYS changed its working name to HVES in 1952, it began to focus on vocational education projects in Israel. Legally, however, the name of the organization in Israel remained Hadassah Youth Services. The Hadassah Council in Israel acted as an advisor and liaison between Hadassah's American offices and Hadassah's Israel projects, including the Hadassah Medical Organization, Youth Aliyah, and Hadassah Youth Services.

The Hadassah Medical Organization Records in the Hadassah Archives document Hadassah's work in providing health care resources in Palestine/Israel since 1918. The activities documented revolve around the development of the Hadassah Hospital; health centers; dental centers; occupational and rehabilitative services; medical, nursing, dental, and pharmacy schools; as well as numerous educative and preventive projects, especially those aimed at infant care. The documents also reflect the history of the Yishuv (Jewish settlement in Palestine) and the establishment of the State of Israel. The record group contains articles, clippings, correspondence, financial records, fundraising material, minutes, personal accounts, press releases, publicity material, reports, and statistical reports.

The materials in this record group document the entirety of Hadassah’s history and work in Israel and the United States in photographs—prints, slides, glass lantern plates, and digital images.

The material in this record group was culled from Hadassah's Central Files in Israel in the early 1980s to document Hadassah's role in Zionist history. Originally formed from a Zionist women's study group, the first Hadassah chapter in New York had a strong relationship with the Zionist Organization of America (ZOA; then known as the Federation of American Zionists). The material in this record group documents Hadassah's relationship to the ZOA and to other Zionist organizations in the United States, Europe, and Palestine/Israel, particularly in the years leading up to Israeli statehood in 1948. Other subjects addressed in this record group include the founding of Hadassah; World War II, particularly relating to Jewish emigration and refugees; the founding of the United Nations and the debate over recognition of a Jewish state; the partition of Palestine; and Arab-Jewish relations. Included are articles, clippings, convention resolutions, correspondence, diary extracts, memorandums, minutes, press releases, printed ephemera, publications, reports, and speeches.