The materials in this collection constitute a semi-random sample of the pre-war archive that was transferred to the Central State Archives of the Lithuanian Soviet Socialist Republic following the liquidation of the Vilnius Jewish Museum in 1949. The collection includes records of YIVO work and activities, financial records, correspondence, and publications; documents about pogroms in Ukraine, and Red Army and Soviet activity in Vilna and Bialystok; and a significant amount of records of socialist, communist, and Zionist political parties, as well as associated newspapers and one-time publications.

The collection consists of the general, personal and professional correspondence of Moses Kligsberg, manuscripts for published and unpublished works, project proposals and outlines, research materials, printed matter and other records relating to Moses Kligsberg's involvement with the Bund and with Jewish refugees from Nazi-occupied Europe, to his functions at the YIVO Institute for Jewish Research, and to his scholarly interests. Included are Moses Kligsberg's manuscripts on the subjects of Jewish sociology, psychology, youth, and political matters. The collection contains a great deal of YIVO administrative and publicity materials, among others editorial records of the Yedies fun yivo (YIVO News) and YIVO radio programs; materials on the Bund; records of the United Jewish Survivors of Nazi Persecution. Besides the personal documents and both personal and organizational correspondence, the collection also includes original musical compositions, acetate recordings, magnetic reels, and photographs.