The bulk of the collection contains documents generated by the Judenrats of the Vilna ghetto during Nazi occupation. The Yiddish poets Abraham Sutzkever and Szmerke Kaczerginski, interned in the Vilna Ghetto before escaping to the forests as partisans, were instrumental in the removal of this collection from Vilna and its subsequent transfer to the YIVO Archives in New York. The collection is therefore named in their honor.

This collection contains the personal and professional papers of Shmuel Mordkhe Zygielbojm, a Jewish-Polish Socialist politician, Bund leader, member of the National Council of the Polish Government-in-Exile in London, and a labor and political leader. These materials include Zygielbojm’s writings, personal correspondence, clippings, and some photographs. These materials relate mainly to Zygielbojm’s work in London as well as the worldwide reactions after his suicide.

Raphael Lemkin, an international lawyer, initiated the use of the term "genocide," and succeeded in persuading the United Nations to adopt the Genocide Convention in 1948. Documents include personal correspondence and artifacts; correspondence, documentation, clippings, and articles regarding the United Nations adoption of the Convention on the Prevention and Punishment on the Crime of Genocide treaty; and source material for the unfinished manuscript, History of Genocide. Collection also includes photographs, identity cards, articles, papers, essays, clippings, magazines, research materials, term papers, posters, United Nations materials, and microfilm.

The collection relates to the life of Jewish refugees, mostly of German and Austrian origin, in Shanghai primarily between the years 1939-1948. It covers many aspects of their experience, including political and cultural events, relief and charity activities, and self-help. The collection originated from the YIVO exhibition that was organized and displayed in 1947 in Shanghai and later in New York. The collection consists of manuscripts, minutes of meetings, correspondence, newspaper clippings, and printed materials.