The Annual and Mid-Winter National Conventions Records document the proceedings and outcomes of the conventions and conferences attended by Hadassah’s National Board as well as by convention delegates from the various regions of Hadassah. The conventions in particular are where local and regional leaders meet with each other and the National Board and learn about Hadassah’s various projects and committees. This record group also includes annual reports from 1926-2001.

This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

Hadassah Functions and Operations Records represent the bulk of aid and services provided to Hadassah's membership, from the 1920s to 2011. Materials found in the record group include correspondence, clippings, press releases, manuals and kits for chapters and members to implement programming and chapter structure, fundraising campaigns, scripts, study guides, programming for local and national meetings, biographical files, and training documentation. Departments documented in the record group include Public Affairs, Education, Women's Health, American Affairs, Zionist and International Affairs, Speakers Bureau, Fundraising, Program, Organization, Outreach and Tourism Departments. Materials related to the general administration of Hadassah are also in the record group; these materials include research and development of projects, archives department correspondence and other materials, Hadassah House administration, and strategic planning. The record group also documents Hadassah's efforts to expand membership outside of the United States, by the development of Hadassah International.

The records of the People's Relief Committee for Jewish War Sufferers consist of correspondence with Jewish communities and relief organizations in Europe, Palestine, Cuba, South America, the United States, and Canada; as well as scrapbooks containing U.S. and Canadian Yiddish and English newspaper clippings and printed promotional literature pertaining to the fundraising activities of the People's Relief Committee in North America and abroad.

The Hadassah Archives documents the activities of Hadassah, the Women's Zionist Organization of America. Founded in 1912, the organization engaged hundreds of thousands of American Jewish women in the Zionist project. Materials include extensive records of its social welfare projects in Palestine and later Israel, such as Youth Aliyah and the Hadassah Medical Organization. Administrative records document the organization's governance, operations, and functions. The collection also includes the papers of Hadassah founder, Henrietta Szold, as well as the organization's national presidents, executive directors, and other important individuals. Additional materials also document Hadassah's organizational activity in the United States such as annual and midwinter conventions and the dozens of active local chapters from all over the United States. Hadassah maintained an active publishing schedule, and the records include hundreds of published newsletters, flyers, and magazines. Other materials include thousands of photographs, extensive audiovisual material, and hundreds of artifacts.

This record group contains personal papers and special collections documenting individuals, both Hadassah members and non-Hadassah members, who were important to Hadassah. Much of the material forming the collections in this record group came from the administrative files of the national office of Hadassah, though some of the material was donated to Hadassah. Key individuals represented within this record group include Hadassah national board members Anna Tulin Elyachar, Bertha S. Schoolman, and Denise Tourover Ezekiel, as well as Jesse Zel Lurie who served as the first professional editor of Hadassah Magazine (originally Hadassah Newsletter) from 1947 to 1980.