This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

Hadassah Functions and Operations Records represent the bulk of aid and services provided to Hadassah's membership, from the 1920s to 2011. Materials found in the record group include correspondence, clippings, press releases, manuals and kits for chapters and members to implement programming and chapter structure, fundraising campaigns, scripts, study guides, programming for local and national meetings, biographical files, and training documentation. Departments documented in the record group include Public Affairs, Education, Women's Health, American Affairs, Zionist and International Affairs, Speakers Bureau, Fundraising, Program, Organization, Outreach and Tourism Departments. Materials related to the general administration of Hadassah are also in the record group; these materials include research and development of projects, archives department correspondence and other materials, Hadassah House administration, and strategic planning. The record group also documents Hadassah's efforts to expand membership outside of the United States, by the development of Hadassah International.

Contains material collected by the Jewish Media Service (JMS) on Jewish films, film company catalogs, resources and information from and about various media centers. The majority of the Jewish Media Service records date from when the JMS operated independently from 1975 to 1987. Types of material found in the collection include articles, brochures, catalogs, correspondence, examination study guides, filmographies, film stills, newsletters, pamphlets, photographs, posters, publications, scripts, and slides.

Collection contains materials generated while Label Katz served in leadership positions with B’nai B’rith from the 1950s through the 1960s; best represented is his tenure as president of B’nai B’rith International between 1959 and 1965, during which Katz concentrated on challenges faced by Soviet Jews, and on the improvement of Jewish education. Materials consist of correspondence, speeches, clippings, photographs, minutes and reports.

The Youth Aliyah Records in the Hadassah Archives document Hadassah's work with multiple international organizations to rescue Jewish children from continental Europe to Palestine from 1933-1945. The collection also documents Hadassah's involvement with Youth Aliyah since 1946 in providing residential, educational, vocational, rehabilitative and therapeutic care for displaced and at-risk youth from around the world.