This record group includes documents created and maintained by the Office of the President, the Office of the Executive Director and the Chair of the Division Coordinators/Directors Committee. Prominent is the Henrietta Szold series, containing correspondence by and to Szold as well as printed materials written by and about her. The files in this record group were created by a national president or executive director, or for their use, or maintained in their office during their years in office. Included are correspondence, minutes, memos, publications, reports and subject files on topics with which these individuals were involved.

The Hadassah Archives documents the activities of Hadassah, the Women's Zionist Organization of America. Founded in 1912, the organization engaged hundreds of thousands of American Jewish women in the Zionist project. Materials include extensive records of its social welfare projects in Palestine and later Israel, such as Youth Aliyah and the Hadassah Medical Organization. Administrative records document the organization's governance, operations, and functions. The collection also includes the papers of Hadassah founder, Henrietta Szold, as well as the organization's national presidents, executive directors, and other important individuals. Additional materials also document Hadassah's organizational activity in the United States such as annual and midwinter conventions and the dozens of active local chapters from all over the United States. Hadassah maintained an active publishing schedule, and the records include hundreds of published newsletters, flyers, and magazines. Other materials include thousands of photographs, extensive audiovisual material, and hundreds of artifacts.

The Youth Aliyah Records in the Hadassah Archives document Hadassah's work with multiple international organizations to rescue Jewish children from continental Europe to Palestine from 1933-1945. The collection also documents Hadassah's involvement with Youth Aliyah since 1946 in providing residential, educational, vocational, rehabilitative and therapeutic care for displaced and at-risk youth from around the world.